Gout is often linked to eating purine-rich foods like red meat, shellfish, and alcohol.
But new research in Arthritis Care & Research shows what you do eat may matter even more than what you avoid.
Women tend to be protected from gout until menopause thanks to estrogen’s uric acid-lowering effects. That led researchers to wonder if lignans—plant compounds transformed by gut bacteria into phytoestrogens—might mimic some of estrogen’s protective benefits.
To find out, scientists analyzed data from the Nurses’ Health Study and the Health Professionals Follow-up Study, covering more than 122,000 adults without gout at baseline. Participants regularly completed detailed food questionnaires, allowing researchers to track intake of four lignans and common whole-grain foods rich in them.
Key findings after 10 years:
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● Highest intake of matairesinol and secoisolariciresinol → 22% lower gout risk
● Cold whole-grain breakfast cereals (≥1 serving/day) → 38% lower gout risk
● Oatmeal or oat bran (≥2×/week) → 22% lower gout risk
● Foods with added bran (≥2×/week) → 16% lower gout risk
● Dark breads and cooked cereals showed no clear benefit
These protective effects remained even after adjusting for body weight, blood pressure, and other dietary factors. Two other lignans, pinoresinol and lariciresinol, were not linked to lower gout risk—likely because beer, which increases gout risk, is a major source.
Bottom line: start your day with a high-fiber, whole-grain breakfast. A bowl of unsweetened granola or muesli with milk or yogurt works well. Oatmeal topped with fruit and nuts is another good choice. You can also sprinkle bran into smoothies or yogurt for a boost.
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