This is one of the most prescribed medicines in the world.
But it’s not safe.
Previous studies have linked this medication to many serious conditions. Including chronic kidney disease and stomach cancer.
Now, a new study published in Mayo Clinic Proceedings adds to its long list of health risks: fatal heart attack.
And it’s not a small rise in risk.
We’re talking 200%
The researchers used information collected by the Atherosclerosis Risk in Communities Study.
It’s extremely detailed and ran for almost 30 years.
The study used 4,346 subjects. The researchers tracked their PPI consumption by inspecting their pill bottles from 1987 to 1989. Then, ten more times from 2011-2013.
The researchers observed the participants until 2016 to see which of them suffered from stroke, coronary heart disease, or heart failure.
None of the subjects had any form of cardiovascular disease at the beginning of the study.
By the end of their investigation, the scientists had made two important discoveries:
1. People who had taken PPIs for more than five years had 2.02 times the risk of suffering a cardiovascular event than people who never took any.
2. They also had 2.21 times the risk of suffering heart failure compared to those who were not taking PPIs.
This study is very powerful. Not only because of its duration and size.
But also because it accounts for numerous health factors among the subjects. Allowing the researchers to control for these factors.
Another strength of the study is that, because they found that longer PPI use increased cardiovascular disease risk more than short use or no use, it is plausible to conclude that the PPIs did cause the heart disease risk.
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