It’s bitter and chewy but according to a new study in the International Journal of Molecular Sciences it shrinks your prostate on a cellular level.
Enlarged prostate is a condition where prostate cells grow and multiply without any biological use, leading to uncomfortable and sometimes serious urinary symptoms.
A natural compound called cucurbitacin B (Cu B) is already known for its anti-inflammatory and antioxidant powers. The study aimed to see if it could help in stopping the unwanted growth of prostate cells too.
After applying the Cu B to BPH-1 cells (a type of cell taken from human prostate tissue) the researchers checked how the cells and their constituent proteins responded.
Their findings were promising.
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1. Cu B prevented the excessive growth of prostate cells.
2. It also promoted apoptosis in the prostate, which means the cells self-destruct. This is a natural way for the body to get rid of cells that aren’t needed or are behaving abnormally, like cancerous ones.
To understand how Cu B does all this, the researchers examined specific genes and proteins related to cell growth and survival. They discovered that Cu B makes more of the proteins p53 and MDM2 in the cells.
P53 is like a guardian in the cell, detecting when something goes wrong and stopping the cell from growing or causing it to die if it’s damaged.
MDM2 is a protein that helps control p53’s activity.
This suggests that Cu B might help to boost this natural safety mechanism in prostate cells.
Another interesting finding was that Cu B also affects other substances released by the cells. It decreases the level of COX-2, a protein involved in inflammation and pain, suggesting that it might also help reduce the inflammation associated with enlarged prostate.
The problem is that, while cucurbitacin B is natural, it is also extremely bitter, and mostly found in wild vegetable species or in less commonly consumed parts of plants.
It is also not currently available as a supplement because scientists believe its ability to cause cell death might make it toxic to humans.