Acid reflux (GERD) is often written-off as a minor condition although it’s actually very serious. And the drugs used to manage it have always been considered quite safe.
But a new study published in the journal Psychotherapy and Psychosomatics reveals potentially deadly side effects from one of the most commonly used heartburn medications.
You must stop or reduce your intake of these drugs right now.
Proton-pump inhibitors (PPIs) are among the most commonly taken drugs in the developed world, often to reduce acid reflux.
Researchers examined the medical data of 2,366 people who took PPIs and developed depression and compared them with 9,464 people who took PPIs and did not develop depression.
The two groups were similar with regard to age, gender, and the amount of time for which the scientists observed them.
But it turned out that those who developed depression used a higher dose of daily PPIs than those without depression.
This was especially true for people who took pantoprazole, lansoprazole, and rabeprazole, and less so for those who took omeprazole and esomeprazole.
And depression is a big deal. The fatality rate for major depression is extremely high.
The researchers didn’t know exactly why this happened, but ventured two educated guesses:
1. They thought it was possible that PPIs prevented people’s bodies from absorbing all the nutrients from their food, leaving them without what was essential for healthy psychological function.
2. Alternatively, they thought PPIs could disrupt the gut–brain axis—a term that refers to the way in which gut bacteria affect our psychological well-being. Since gut bacteria can boost or block levels of hormones and neurotransmitters in our brains, they can determine our psychological health.
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