By now we all know that type 2 diabetes damages our blood vessels.
That is why so many diabetics are at risk of limb amputations, blindness, heart attack, and stroke. These problems arise when blood circulation to limbs, retina, heart, and brain is cut off.
Endothelial cells lining your blood vessel walls are supposed to keep your blood vessel walls strong.
When these endothelial cells are damaged, the walls of your blood vessels start to disintegrate, which leads to a condition medical scientists call vascular leakiness.
…which is very often leads to blindness.
This is part of what happens to diabetics, but their problem is even worse.
When their bodies try to replace the leaky blood vessels, they don’t create normal new vessels, they create more leaky vessels.
Therefore, once diabetes has damaged your blood vessels, your body just produces more and more damaged blood vessels to replace them.
This is the process that gives rise to diabetic retinopathy, the scientific term for the blindness from which diabetics suffer.
Up to now, researchers have believed that the culprit behind this vascular leakiness was a molecule called vascular endothelial growth factor (VEGF).
Despite drugs designed to stop VEGF, they fail for twice as many patients they work.
In fact, since vascular endothelial growth factor is essential for your body to produce healthy blood vessels, suppressing it doesn’t seem like a great idea.
Scientists at Bascom Palmer Eye Institute at the University of Miami Miller School of Medicine have now discovered a mechanism that may be responsible for the vascular leakiness that gives rise to diabetic blindness in a study on mice.
They found a protein called secretogranin III is another culprit in degeneration of blood vessel walls. While they were able to block this protein in mice, it’s a treatment that is a long way off for humans.