If left untreated, nonalcoholic fatty liver disease (NAFLD) can lead to severe liver conditions like fibrosis and even liver cancer.
And there is no effective medical solution for NAFLD.
A recent study published in the journal Nutrition & Diabetes has found a plant that can drastically reverse, even heal, NAFLD.
Alantolactone is a substance extracted from plants in the Asteraceae family. It’s known for its anti-inflammatory properties, but its effects on liver disease were not well understood before this study.
To explore alantolactone’s potential, researchers conducted a study on mice and liver cells.
First, they fed a group of C57BL/6 mice a high-fat diet for 16 weeks. This diet caused the mice to develop NAFLD, mimicking the disease process in humans.
After 16 weeks, they started giving some of the mice alantolactone by mouth. They continued this treatment to observe its effects on liver disease.
In addition to the mouse experiments, the researchers used a mouse liver cell line called AML-12. They treated these cells with alantolactone before exposing them to palmitic acid, a fatty acid that can induce inflammation and oxidative stress, similar to what happens in NAFLD.
The findings from these studies were quite promising.
-
1. Mice treated with alantolactone showed much lower levels of liver inflammation.
2. Alantolactone also reduced the development of liver fibrosis, a dangerous thickening and scarring of liver tissue.
3. In both the mice and the liver cells, alantolactone reduced oxidative stress, which is a harmful process that can damage cells and tissues.
The researchers didn’t just stop at observing these beneficial effects; they also dug deeper to understand how alantolactone works, and found two mechanisms.
-
1. It helps activate a protein called Nrf2, which plays a crucial role in protecting cells from oxidative stress.
2. It inhibits NF-Kappa-B, a protein complex that controls inflammation. By blocking this pathway, alantolactone can reduce inflammation in the liver.
So, alantolactone has a protective effect on the liver by reducing inflammation and oxidative stress. This makes it a promising candidate for treating NAFLD.
The only problem at this stage is that alantolactone is only available for sale to researchers and laboratories.