Pharmaceutical creams are surprisingly ineffective in killing nail fungus. And they come with a row of side effects.
Alternative methods come with their own problems. They, for example, often don’t work in their natural forms.
A new study in Medicine in Drug Discovery attempted to combine science with alternative approaches. The results were nothing short of miraculous.
Zataria multiflora, a plant native to Iran, Afghanistan, and Pakistan, is known for its potent antifungal properties, thanks to its rich content of flavonoids and phenols.
However, there is a problem. The particles in this oil are too big to penetrate our nails well enough to kill the fungi.
In response, the authors of this new study developed a gel containing Zataria multiflora and loaded it into a nanoparticle carrier oil. Nanoparticles are tiny particles that are small enough to penetrate our nails. As such, they can help deliver the medication more effectively.
The scientists then conducted a study with 40 volunteers who had nail fungus caused by Candida.
The participants were divided into two groups: one group received the Zataria multiflora gel, and the other group received a fake gel with no medication. Neither the volunteers nor the researchers knew which gel each volunteer was receiving.
The volunteers were told to apply the gel twice a day for four weeks, and the researchers assessed them at the beginning of the study, after two weeks, and after four weeks.
They looked at signs and symptoms of the infection, such as inflammation and pain, as well as test results to confirm the presence of fungus.
What were the results?
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1. The group receiving Zataria multiflora showed significant improvement in symptoms like inflammation and pain after just two weeks of treatment, compared to the fake treatment group.
2. After both two and four weeks, the Zataria multiflora group showed a larger improvement when researchers visually inspected their nails.
3. Test results to detect fungus also showed improvement in the Zataria multiflora group after both two and four weeks.
Therefore, a treatment that combines Zataria multiflora gel with a nanoparticle carrier oil is a safe and effective treatment for candida-associated fungal nail infections. In fact, it worked more rapidly than most treatments for this condition do, as confirmed by the dermatologists and mycologists (funky specialists) who were part of the study.
Now, the only problem is that this treatment is not yet commercially available, but we can always hope that such positive results will motivate the scientific community to move ahead with it.