When newly diagnosed Type 2 diabetes patients are counseled, one of the first complications of the disease that is listed is heart attack.

Studies have shown for years that the people with diabetes are at more than twice as likely to die from a heart attack as those who are not diabetic, but the reason why has been unclear, until now.

Researchers looking at diabetic mice after a heart attack have found a critical piece to the puzzle as to why Type 2 diabetes might lead to heart attack.

A critical enzyme that plays a role in the health of pacemaker cells in the heart is found to be startlingly overactive in diabetic mice, leading to the death of the pacemaker cells, which help manage rhythm.

An abnormal heart rhythm can lead to sudden death, not only in mice, but also especially in humans.

Diabetes’ role in the stimulation of this enzyme is that the enzyme is increased under oxidative stress, which occurs in the cells of diabetic patients.

This oxidative stress, compounding the death of pacemaker cells, is what scientists were able to trace as the reason death after a heart attack was twice as likely in diabetic mice as non-diabetic mice.

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